| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biophysical Journal 1: 1-14 (1960)
© 1960 the Biophysical Society
ABSTRACT
Measurements of the potassium current in the squid axon membrane have been made, after changes of the membrane potential to the sodium potential of Hodgkin and Huxley (HH), from near the resting potential, from depolarizations of various durations and amplitudes, and from hyperpolarizations of up to 150 mv. The potassium currents I given by I = I
{1 - exp [- (t + t0)/
]}25, where t0 is determined by the initial conditions, represent the new data and approximate the HH functions in the regions for which they are adequate. A corresponding modification for the sodium current does not appear necessary. The results support the HH assumptions of the independence of the potassium and sodium currents, the dependence of the potassium current upon a single parameter determined by the membrane potential, and the expression of this parameter by a first order differential equation, and, although the results drastically modify the analytical expressions, they very considerably extend the range of apparent validity of these assumptions. The delay in the potassium current after severe hyperpolarization is used to estimate a potassium ion mobility in the membrane as 10-5 of its value in aqueous solutions.
This article has been cited by other articles:
 |
|
 |
|
  F. V. Campos, B. Chanda, P. S.L. Beirao, and F. Bezanilla {beta}-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel J. Gen. Physiol., August 27, 2007; 130(3): 257 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Dekker and G. Yellen Cooperative Gating between Single HCN Pacemaker Channels J. Gen. Physiol., November 1, 2006; 128(5): 561 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Klassen, S. D. Buckingham, D. M. Atherton, J. B. Dacks, W. J. Gallin, and A. N. Spencer Atypical Phenotypes From Flatworm Kv3 Channels J Neurophysiol, May 1, 2006; 95(5): 3035 - 3046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Filatov, M. J. Pinter, and M. M. Rich Resting Potential-dependent Regulation of the Voltage Sensitivity of Sodium Channel Gating in Rat Skeletal Muscle In Vivo J. Gen. Physiol., July 25, 2005; 126(2): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kuzmenkin, F. Bezanilla, and A. M. Correa Gating of the Bacterial Sodium Channel, NaChBac: Voltage-dependent Charge Movement and Gating Currents J. Gen. Physiol., September 27, 2004; 124(4): 349 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Bhumbra and R. E. J. Dyball Measuring spike coding in the rat supraoptic nucleus J. Physiol., February 15, 2004; 555(1): 281 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, M. Zhang, M. Jiang, and G.-N. Tseng Negative Charges in the Transmembrane Domains of the HERG K Channel Are Involved in the Activation- and Deactivation-gating Processes J. Gen. Physiol., May 27, 2003; 121(6): 599 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Boyle, E. Azhderian, N. MacLusky, F Naftolin, and L. Kaczmarek Xenopus oocytes injected with rat uterine RNA express very slowly activating potassium currents Science, March 6, 1987; 235(4793): 1221 - 1224. [Abstract] [PDF]
|
|
|
|
|
|
G. Eisenman, J. P. Sandblom, and J. L. Walker Jr. Membrane Structure and Ion Permeation Science, February 24, 1967; 155(3765): 965 - 974. [PDF]
|
|
|
|
|
|
A. F. Huxley Excitation and Conduction in Nerve: Quantitative Analysis Science, September 11, 1964; 145(3637): 1154 - 1159. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
