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Biophysical Journal 1: 323-336 (1961)
© 1961 the Biophysical Society

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The Replication of DNA

II. The Number of Polynucleotide Strands in the Conserved Unit of DNA

Liebe F. Cavalieri and Barbara Hatch Rosenberg

ABSTRACT

The kinetics of degradation of DNA by deoxyribonuclease II have been studied, using the techniques of light scattering, viscosity, and titration. Theoretical equations have been derived for both random and non-random attacks, and all assumptions have been evaluated. It has been shown that these equations permit a valid calculation of the number of polynucleotide strands per molecule. The results have been verified by two independent experimental methods. DNA from proliferating sources was found to be four-stranded; DNA from non-proliferating sources was found to be two-stranded. The implications of these findings are discussed.






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Copyright © 1961 by the Biophysical Society.