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Biophysical Journal 10: 74-79 (1970)
© 1970 the Biophysical Society

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Sizing Particles with a Coulter Counter

James Hurley

ABSTRACT

A theorem is presented which permits a determination of the amplitude of the signal generated by the passage of a particle of arbitrary shape through a Coulter counter. The theorem is applied to particles of two shapes, a sphere and a prolate spheroid. For the sphere the signal is directly proportional to the volume of the particle. For the spheroid the result is a complicated function of the shape. Two spheroids of the same volume but different shapes will give different signals.






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Copyright © 1970 by the Biophysical Society.