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Biophysical Journal 10: 305-315 (1970)
© 1970 the Biophysical Society

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Reactions between Singlet Oxygen and the Constituents of Nucleic Acids

Importance of Reactions in Photodynamic Processes

F. R. Hallett, B. P. Hallett and W. Snipes

ABSTRACT

Bases, nucleosides, nucleotides, and polynucleotides were exposed to chemically generated singlet oxygen to determine whether the species oxidized paralleled those oxidized in photodynamic reactions. In neutral or basic aqueous solution guanine, guanosine, deoxyguanosine, guanylic acid, deoxyguanylic acid, thymine, and uracil reacted with singlet oxygen. Since these compounds are oxidized in photodynamic processes, this study provides further evidence that singlet oxygen is the active intermediate in the photodynamic oxidation of nucleic acid constituents. Dienophilic attack by singlet oxygen is considered to be a plausible mechanism in these reactions.






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Copyright © 1970 by the Biophysical Society.