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Biophysical Journal 10: 509-518 (1970)
© 1970 the Biophysical Society

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The Dampening of DNA Replication Cycles after X-Irradiation or Ultraviolet Light Irradiation

Daniel Billen and Laura H. Bruns

ABSTRACT

Escherichia coli strains 15T- (555-7) and B/r were grown in the presence of thymine-14C to label all DNA. The ability of these parental DNA's to undergo cycles of replication subsequent to cellular irradiation with either X-ray or ultraviolet light (UV) was followed with density labels. Exposed cells were shifted into the density medium at times which were approximately multiples of normal rounds of DNA replication. A portion of the parental DNA, replicated semiconservatively once during an initial cycle following UV or X-irradiation in E. coli, failed to replicate again within the time studied. The time course of semiconservative parental DNA replication is altered.






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Copyright © 1970 by the Biophysical Society.