Biophysical Journal 11: 110-122 (1971)
© 1971 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hoyt, R. C. Search for Related Content PubMed PubMed Citation Articles by Hoyt, R. C.

Independence of the Sodium and Potassium Conductance Channels

A Kinetic Argument

ABSTRACT

Tightly coupled models for the sodium and potassium conductance changes, in which the potassium "on" process is intimately related to the sodium "on" and "off" processes, are studied. It is shown that such coupled models are incapable of simultaneously showing the observed effects of conditioning potentials on sodium inactivation and on the translation of the potassium conductance in time. It is concluded that the primary mechanisms for the sodium and potassium channels are probably independent.

This article has been cited by other articles:

				B. W. Jarecki, P. L. Sheets, J. O. Jackson II, and T. R. Cummins Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation J. Physiol., September 1, 2008; 586(17): 4137 - 4153. [Abstract] [Full Text] [PDF]