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Biophysical Journal 11: 550-557 (1971)
© 1971 the Biophysical Society

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Dipole Moment of Acetylcholine and Its Relevance to the Chemical Synaptic Transmission

Patrick Maurel and Lauro Galzigna

ABSTRACT

The dipole moment of acetylcholine (AcCh) has been measured in chloroform and a value of 8.49 D was obtained. Such a value actually represents the total dipole moment of the ion pair (AcCh)+(Cl)-. The dipole moment of the (AcCh)+ cation alone turned out to be 2.65 D whereas its theoretical value obtained after a vectorial calculation was 1.65 D. The discrepancy was related to an interaction between AcCh and the solvent. The meaning of the measured value is discussed on the basis of a recent theory of chemical synaptic transmission based on the assumption of a much higher dipole moment value for the AcCh molecule.






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Copyright © 1971 by the Biophysical Society.