Biophysical Journal 12: 1132-1144 (1972)
© 1972 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sabah, N. H. Articles by Leibovic, K. N. Search for Related Content PubMed PubMed Citation Articles by Sabah, N. H. Articles by Leibovic, K. N.

The Effect of Membrane Parameters on the Properties of the Nerve Impulse

ABSTRACT

The effect of varying membrane capacitance, conductance, and rate constants on the properties of the nerve impulse is considered in terms of the degree of regeneration in the Hodgkin-Huxley model for the squid giant axon. It is shown through computer simulation that reducing regeneration generally increases the duration of the action potential and decreases its amplitude, rate of rise, and conduction velocity. The threshold becomes much less sharp and the amplitude of the response of a patch of membrane grades with stimulus strength. A second stimulus, applied shortly after a first stimulus, considerably perturbs the membrane potential from its original time-course. Under certain conditions, the nerve signal can propagate with a small decrement.

This article has been cited by other articles:

				G. A Jacobson, K. Diba, A. Yaron-Jakoubovitch, Y. Oz, C. Koch, I. Segev, and Y. Yarom Subthreshold voltage noise of rat neocortical pyramidal neurones J. Physiol., April 1, 2005; 564(1): 145 - 160. [Abstract] [Full Text] [PDF]