Biophysical Journal 13: 1071-1089 (1973)
© 1973 the Biophysical Society

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Propagation Speed in Myelinated Nerve

II. Theoretical Dependence on External Na⁺ and on Temperature

ABSTRACT

The Hodgkin-Huxley (H.H.) equations modified by Dodge for Rana pipiens myelinated nerve have been solved to determine how well the theory predicts the effects of changes of temperature and [Na⁺]₀ on propagation. Conduction speed was found to have an approximately exponential dependence on temperature as was found experimentally, but the theoretical temperature coefficient (Q₁₀) was low; 1.5 compared with the experimental finding of 2.95. was found to be a linear function of log ([Na⁺]₀) in contrast to the experimental finding of a square root dependence on [Na⁺]₀. is 50% greater at one-fourth normal [Na⁺]₀ than the theory predicts. The difference between the theoretical ([Na⁺]₀) and the experimental ([Na⁺]₀) is probably due to an imprecisely known variation of parameters and not to a fundamental inadequacy of the theory.

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