Biophysical Journal 13: 546-567 (1973)
© 1973 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stephenson, J. L. Search for Related Content PubMed PubMed Citation Articles by Stephenson, J. L.

Concentrating Engines and the Kidney

II. Multisolute Central Core Systems

ABSTRACT

The analysis of the central core model of the renal medulla is extended to multisolute systems. It is shown that total solute concentration obeys the same differential equations for core and ascending limb as in a single solute system. Equations are derived for the concentration of individual solutes. Application of these equations to a two solute system shows that a central core system can concentrate with all transport being down a concentration gradient. This analysis applied to the renal medulla shows that mixing of urea from the collecting duct (CD) and salt from the loop of Henle in the central core of the inner medulla contributes to the concentration of urine during antidiuresis. It also sets criteria for completely passive function of the loop in the inner medulla, but whether these are satisfied cannot be determined from present experimental data.

This article has been cited by other articles:

				D. J . Marsh Simulation of Biological Systems: the Kidney SIMULATION, April 1, 1977; 28(4): 197 - 200. [PDF]