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Biophysical Journal 13: 581-593 (1973)
© 1973 the Biophysical Society

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The Interaction of the Polyene Antibiotic Lucensomycin with Cholesterol in Erythrocyte Membranes and in Model Systems

II. Cooperative Effects in Erythrocyte Membranes

Roberto Strom, Carlo Crifò and Antonio Scioscia Santoro

ABSTRACT

Fluorometric titration curves of erythrocyte membranes with increasing lucensomycin have a sigmoid shape. This behavior, which was not present when colloidal cholesterol suspensions were used, is, however, not peculiar to the membrane structure, being also present in cholesterol-containing phospholipid micelles. Addition of acetic acid induced or increased sigmoidicity. This behavior can either be due to a true cooperativity in binding or to different fluorescence yields of the various lucensomycin-membrane complexes. The latter hypothesis appears to be slightly favored.






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Copyright © 1973 by the Biophysical Society.