Biophysical Journal 14: 703-729 (1974)
© 1974 the Biophysical Society

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Direct Determination of the Lamellar Structure of Peripheral Nerve Myelin at Moderate Resolution (7 Å)

ABSTRACT

Low-angle X-ray diffraction patterns have been recorded from normal nerve and nerve swollen in glycerol solutions. The new X-ray data have a resolution of 7 Å. Direct methods of structure analysis which include deconvolution of the auto-correlation function and sampling theorem reconstructions have been used in the interpretation of the X-ray data. Phases have been assigned to the first 12 orders of diffraction from normal nerve. Fourier syntheses at a resolution of 7 Å are described and an absolute electron density scale is derived. A possible molecular interpretation of the electron density profile is given.