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Biophysical Journal 15: 287-298 (1975)
© 1975 the Biophysical Society

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Kinetics of lysosomal storage of indigestible matter.

J Hurley and J Alward

ABSTRACT

In lysosomal storage diseases and in accumulation of lipofusion in the lysosomes there is a gradual eroding of the lysosomal system due to overloading the lysosomes by molecules which cannot be digested or expelled. The kinetics of this accumulation is examined for tissue cultures in terms of the cell growth rate, lysosomal production rate, and of generation of the indigestible element.






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Copyright © 1975 by the Biophysical Society.