help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Biophysical Journal 15: 577-590 (1975)
© 1975 the Biophysical Society

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jakobsson, E
Right arrow Articles by Scudiero, C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jakobsson, E
Right arrow Articles by Scudiero, C

A transient excited state model for sodium permeability changes in excitable membranes.

E Jakobsson and C Scudiero

ABSTRACT

In this paper we explore the properties of a mathematical model for the passive sodium permeability system of excitable membranes. This model is distinguished by the explicit inclusion of a rate constant which depends not on instantaneous voltage, but on rate of voltage change. Actually, the model is a rather modest modification of the Hodgkin-Huxley model, but displays some behaviors which the H-H model does not. Among these behaviors are a pronounced inactivation shift (for certain parameter values), a difference between inactivation time constant as measured by turning off a sodium current under sustained depolarization and as measured by double pulse experiments, skip runs under sustained current stimulation, and accommodation to slowing rising currents.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the Biophysical Society.