Biophysical Journal 16: 771-778 (1976)
© 1976 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schauf, C L Articles by Davis, F A Search for Related Content PubMed PubMed Citation Articles by Schauf, C L Articles by Davis, F A

Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state.

ABSTRACT

Sodium inactivation and reactivation have been examined in voltage-clamped Myxicola axons after long-lasting membrane depolarizations produced either directly by changes in holding potential or indirectly by elevation of external K+ concentration. The results suggest the existence of a second inactivated state of the sodium channel with associated voltage-dependent rate constants at least two orders of magnitude lower than those of the fast inactivation process commonly examined. No specific influence of external [K+] on slow Na+ inactivation could be detected.

This article has been cited by other articles:

				A. Toib, V. Lyakhov, and S. Marom Interaction between Duration of Activity and Time Course of Recovery from Slow Inactivation in Mammalian Brain Na+ Channels J. Neurosci., March 1, 1998; 18(5): 1893 - 1903. [Abstract] [Full Text] [PDF]

				H.-Y. Jung, T. Mickus, and N. Spruston Prolonged Sodium Channel Inactivation Contributes to Dendritic Action Potential Attenuation in Hippocampal Pyramidal Neurons J. Neurosci., September 1, 1997; 17(17): 6639 - 6646. [Abstract] [Full Text] [PDF]