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Biophysical Journal 17: 269-274 (1977)
© 1977 the Biophysical Society

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Evidence that nystatin may not form channels in thin lipid membranes.

W O Romine, G R Sherette, G B Brown and R J Bradley

ABSTRACT

The mechanism of nystatin-induced conductance increases in planar bilayer membranes formed from lecithin/cholesterol (1:1) has been examined by spectral analysis of kinetic fluctuations. Lorentzian components of the power spectrum, characteristic of channel activity, were not observed for nystatin-doped membranes. Instead, the noise associated with this system (approximately 10(-27)A2/Hz) was in better agreement with that expected of a carrier mechanism involved in the transport of single charges in uncorrelated fashion. The implications of this result with respect to previous models of nystatin-induced conductance increases are discussed.




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R. Bradley, D. Urry, K Okamoto, and R Rapaka
Channel structures of gramicidin: characterization of succinyl derivatives
Science, April 28, 1978; 200(4340): 435 - 437.
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Copyright © 1977 by the Biophysical Society.