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Biophysical Journal 19: 307-313 (1977)
© 1977 the Biophysical Society

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In situ observation of dense-body release from hydrated human platelets.

J L Costa

ABSTRACT

Human-platelet dense bodies (secretory granules) have been visualized by electron microscopy in cells maintained in a hydrated state, and their sequential release after stimulation by thrombin has been observed in situ. The pattern of dense body release from individual platelets suggests that a a portion of the dense body complement of a single cell can be extruded without appreciable change in the position of the remaining dense bodies.




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J. Costa, D. Joy, D. Maher, K. Kirk, and S. Hui
Fluorinated molecule as a tracer: difluoroserotonin in human platelets mapped by electron energy-loss spectroscopy
Science, May 5, 1978; 200(4341): 537 - 539.
[Abstract] [PDF]


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Copyright © 1977 by the Biophysical Society.