Biophysical Journal 2: 179-198 (1962)
© 1962 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mauro, A. Search for Related Content PubMed Articles by Mauro, A.

Space Charge Regions in Fixed Charge Membranes and the Associated Property of Capacitance

ABSTRACT

The Poisson-Boltzmann equation, which was derived by Shockley in his treatment of the p-n semiconductor junction at equilibrium, is applied to fixed charge ionic membranes. The fixed charges in ionic membranes play the same role as "doping" ions in semiconductors, the major difference between the two systems being that in the former the mobile particles are ions while in the latter the particles are electrons and phenomenological particles, "holes." An important consequence of spatial gradients of fixed charge is the presence of space charge regions which give rise to an intrinsic electric field and potential. These quantities are established first for the single "lattice" thus providing a continuous treatment of the Donnan equilibrium invoked by Teorell-Meyer-Sievers in their treatment of fixed charge membranes. It is shown further that when a positive and negative membrane are juxtaposed, the space charge region in the "junction" so formed provides a mechanism for the storage of electrical energy. Thus while the system is basically a "conductor" the presence of transition regions of fixed charge give rise to the additional property of capacitance. Experimental data are presented on ionic and p-n junctions. The implications of this mechanism for the physical basis of capacitance in biological cells are discussed.