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Biophysical Journal 2: 235-247 (1962)
© 1962 the Biophysical Society

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Studies on the Sonic Degradation of Deoxyribonucleic Acid

David Freifelder and Peter F. Davison

ABSTRACT

T7 DNA was partially degraded by x-rays, DNAase, and sonic irradiation. The molecular weight distributions were calculated from sedimentation velocity studies on the resulting preparations. Comparison with the theoretical curve derived by Montroll and Simha showed that the first two degradative methods act grossly at random, whereas sonication is a non-random process resulting in the preferential halving of the DNA molecules in solution.




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E. L. Hess, P. W. L. Chun, and R. L. Crowley
Sonic Energy Effects in Bovine Serum Albumin Solutions
Science, March 13, 1964; 143(3611): 1176 - 1177.
[Abstract] [PDF]


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Copyright © 1962 by the Biophysical Society.