Biophysical Journal 2: 289-316 (1962)
© 1962 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Berman, M. Articles by Weiss, M. F. Search for Related Content PubMed PubMed Citation Articles by Berman, M. Articles by Weiss, M. F.

Some Formal Approaches to the Analysis of Kinetic Data in Terms of Linear Compartmental Systems

ABSTRACT

A formal approach to the routine analysis of kinetic data in terms of linear compartmental systems is presented. The methods of analysis are general in that they include much of the theory in common use, such as direct solution of differential equations, integral equations, transfer functions, fitting of data to sums of exponentials, matrix solutions, etc. The key to the formalism presented lies in the fact that a basic operational unit—called "compartment"—has been defined, in terms of which physical and mathematical models as well as input and output functions can be expressed. Additional features for calculating linear combinations of functions and for setting linear dependence relations between parameters add to the versatility of this method. The actual computations for the values of model parameters to yield a least squares fit of the data are performed on a digital computer. A general computer program was developed that permits the routine fitting of data and the evolution of models.

This article has been cited by other articles:

				A. B. Clymer and G.F. Graber Trends in the Development and Applications of Analog Simulations in Biomedical Systems SIMULATION, April 1, 1964; 2(4): 41 - 58. [PDF]