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Biophysical Journal 20: 193-219 (1977)
© 1977 the Biophysical Society
ABSTRACT
Statistical fluctuations limit the precision with which a microorganism can, in a given time T, determine the concentration of a chemoattractant in the surrounding medium. The best a cell can do is to monitor continually the state of occupation of receptors distributed over its surface. For nearly optimum performance only a small fraction of the surface need be specifically adsorbing. The probability that a molecule that has collided with the cell will find a receptor is Ns/(Ns + pi a), if N receptors, each with a binding site of radius s, are evenly distributed over a cell of radius a. There is ample room for many indenpendent systems of specific receptors. The adsorption rate for molecules of moderate size cannot be significantly enhanced by motion of the cell or by stirring of the medium by the cell. The least fractional error attainable in the determination of a concentration c is approximately (TcaD) - 1/2, where D is diffusion constant of the attractant. The number of specific receptors needed to attain such precision is about a/s. Data on bacteriophage absorption, bacterial chemotaxis, and chemotaxis in a cellular slime mold are evaluated. The chemotactic sensitivity of Escherichia coli approaches that of the cell of optimum design.
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|
|
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|
|
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|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 D. K. Button Nutrient Uptake by Microorganisms according to Kinetic Parameters from Theory as Related to Cytoarchitecture Microbiol. Mol. Biol. Rev., September 1, 1998; 62(3): 636 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
D. B. Dusenbery Minimum size limit for useful locomotion by free-swimming microbes PNAS, September 30, 1997; 94(20): 10949 - 10954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 J. Parkinson and D. Blair Does E. coli have a nose? Science, March 19, 1993; 259(5102): 1701 - 1702. [PDF]
|
|
|
|
|
|
Maddock JR and L Shapiro Polar location of the chemoreceptor complex in the Escherichia coli cell Science, March 19, 1993; 259(5102): 1717 - 1723. [Abstract] [PDF]
|
|
|
|
|
|
S. Chung, P. Reinhart, B. Martin, D Brautigan, and I. Levitan Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel Science, August 2, 1991; 253(5019): 560 - 562. [Abstract] [PDF]
|
|
|
|
|
|
J. Weaver and R. Astumian The response of living cells to very weak electric fields: the thermal noise limit Science, January 26, 1990; 247(4941): 459 - 462. [Abstract] [PDF]
|
|
|
|
 |
|
 H.C. Berg Bacterial Microprocessing Cold Spring Harb Symp Quant Biol, January 1, 1990; 55(0): 539 - 545. [Abstract] [PDF]
|
|
|
|
|
|
H.C. Berg A Physicist Looks at Bacterial Chemotaxis Cold Spring Harb Symp Quant Biol, January 1, 1988; 53(0): 1 - 9. [Abstract] [PDF]
|
|
|
|
|
|
M. P. McGee and T. Chou Surface-dependent Coagulation Enzymes. FLOW KINETICS OF FACTOR Xa GENERATION ON LIVE CELL MEMBRANES J. Biol. Chem., March 9, 2001; 276(11): 7827 - 7835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. He, T. J. Melia, C. W. Cowan, and T. G. Wensel Dependence of RGS9-1 Membrane Attachment on Its C-terminal Tail J. Biol. Chem., December 21, 2001; 276(52): 48961 - 48966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Shvartsman, M. P. Hagan, A. Yacoub, P. Dent, H. S. Wiley, and D. A. Lauffenburger Autocrine loops with positive feedback enable context-dependent cell signaling Am J Physiol Cell Physiol, March 1, 2002; 282(3): C545 - C559. [Abstract] [Full Text] [PDF]
|
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