Biophysical Journal 26: 319-324 (1979)
© 1979 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wanke, E Articles by Testa, P L Search for Related Content PubMed PubMed Citation Articles by Wanke, E Articles by Testa, P L

K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axon membrane.

ABSTRACT

In the range of pH examined (5.2-10), variations of internal pH from high to low values result in a reversible decrease of the conductance of the open K channels, without significantly affecting the kinetics parameters. A linear plot of the conductance versus internal pH suggests the existence of a titratable group that has an apparent pKa of about 6.9, and that is accessible to protons only from the intracellular side of the membrane.

This article has been cited by other articles:

				T. Kelly and J. Church pH modulation of currents that contribute to the medium and slow afterhyperpolarizations in rat CA1 pyramidal neurones J. Physiol., January 15, 2004; 554(2): 449 - 466. [Abstract] [Full Text] [PDF]

				J. R. Clay and A. Shrier Action Potentials Occur Spontaneously in Squid Giant Axons with Moderately Alkaline Intracellular pH Biol. Bull., October 1, 2001; 201(2): 186 - 192. [Abstract] [Full Text] [PDF]

				R. J. LEONARD and J. E. LISMAN Light Modulates Voltage-Dependent Potassium Channels in Limulus Ventral Photoreceptors Science, June 12, 1981; 212(4500): 1273 - 1275. [Abstract] [PDF]