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Biophysical Journal 3: 459-468 (1963)
© 1963 the Biophysical Society

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Properties of Double-Stranded DNA as a Polyelectrolyte

Tsuyoshi Ohnishi

ABSTRACT

The stability of the structure of double-stranded DNA in the salt-free solution is discussed on the basis of the polyelectrolyte theory. Assuming that DNA is an infinitely long rod, and the formation of double strands is divided into combining process and folding process, the free energy changes required in these processes are calculated by the use of the exact solutions of two-dimensional Poisson-Boltzmann equation for the one rod and the two rod systems.

By strong depression of electrostatic interaction due to counter-ion condensation phenomena, the free energy change is remarkably decreased so that the double-stranded structure of DNA can be stabilized by energy of hydrogen bonds between base pairs. The increase of the activity coefficient of a counterion upon heat denaturation of DNA is also explained.






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Copyright © 1963 by the Biophysical Society.