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Biophysical Journal 30: 517-521 (1980)
© 1980 the Biophysical Society

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A comparison of herpes simplex virus plaque development after viral treatment with anti-DNA or antilipid agents.

T P Coohill, M Babich, W D Taylor and W Snipes

ABSTRACT

The plaque development of Herpes simplex virus type 1 (HSV) is slower for viruses treated with two anti-DNA agents: ultraviolet radiation (UV) or n-acetoxy-2-acetyl-aminofluorene. For HSV treated with three antimembrane agents--butylated hydroxytoluene, acridine plus near UV radiation, or ether--the plaque development time is the same as for untreated viruses. These differences hold even for viruses that survived treatment that lowered viability below the 1% level. Gamma ray inactivation of HSV produces no change in plaque development even though this agent is believed to preferentially affect viral DNA.







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Copyright © 1980 by the Biophysical Society.