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Biophysical Journal 33: 323-351 (1981)
© 1981 the Biophysical Society
ABSTRACT
The relationship between calcium current and transmitter release was studied in squid giant synapse. It was found that the voltage-dependent calcium current triggers the release of synaptic transmitter in direct proportion to its magnitude and duration. Transmitter release occurs with a delay of approximately 200 mus after the influx of calcium. A model is presented which describes these relations formally.
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M. Bennett, N Calakos, and R. Scheller Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones Science, July 10, 1992; 257(5067): 255 - 259. [Abstract] [PDF]
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R Llinas, M Sugimori, and R. Silver Microdomains of high calcium concentration in a presynaptic terminal Science, May 1, 1992; 256(5057): 677 - 679. [Abstract] [PDF]
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R. Zucker and L Lando Mechanism of transmitter release: voltage hypothesis and calcium hypothesis Science, February 7, 1986; 231(4738): 574 - 579. [Abstract] [PDF]
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J. Bai, C. A. Earles, J. L. Lewis, and E. R. Chapman Membrane-embedded Synaptotagmin Penetrates cis or trans Target Membranes and Clusters via a Novel Mechanism J. Biol. Chem., August 11, 2000; 275(33): 25427 - 25435. [Abstract] [Full Text] [PDF]
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J. Bai, P. Wang, and E. R. Chapman C2A activates a cryptic Ca2+-triggered membrane penetration activity within the C2B domain of synaptotagmin I PNAS, February 5, 2002; 99(3): 1665 - 1670. [Abstract] [Full Text] [PDF]
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I. Bezprozvanny, P. Zhong, R. H. Scheller, and R. W. Tsien Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating PNAS, December 5, 2000; 97(25): 13943 - 13948. [Abstract] [Full Text] [PDF]
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