Biophysical Journal 33: 383-408 (1981)
© 1981 the Biophysical Society

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A cleft model for cardiac Purkinje strands.

ABSTRACT

Conduction of the action potential in cardiac muscle is complicated by its multicellular structure, with narrow intercellular clefts and cell-to-cell coupling. A model is developed from anatomical data to describe cardiac Purkinje strands of variable diameter and different internal arrangements of cells. The admittance of the model is solved analytically and fit to results of cable analysis. Using the extracted specific membrane and cell electrical parameters (Rm = 13 K omega cm2, Cm = 1.5 mu F/cm2, Ri = 100 mu cm, and Re = 50 omega cm), the model correctly predicted conduction velocity and filling of capacitance at the onset of a voltage step. The analysis permits more complete studies of the factors controlling conduction velocity; for instance, the effect on conduction velocity of a capacity in the longitudinal current circuit is discussed. Predictions of the impedance and phase angle were also made. Measurements of the frequency dependence of phase angle may provide a basis for separating cleft membrane properties from those of the surface membrane and may aid the measurement of nonlinear membrane properties in muscle.