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Biophysical Journal 35: 17-22 (1981)
© 1981 the Biophysical Society

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DNA repair in human fibroblasts treated with a combination of chemicals.

F E Ahmed and R B Setlow

ABSTRACT

Excision repair of DNA damage was measured by the photolysis of bromodeoxy-uridine incorporated during repair in normal human and xeroderma pigmentosum group C fibroblasts (XP C) treated with a combination of the carcinogens N-acetoxy-2-acetylamino-fluorene (AAAF), and 4-nitroquinoline 1-oxide (4NQO). Repair was additive in normal and XP C cells treated with AAAF plus 4NQO, indicating that there are different rate limiting steps for removal of 4NQO and AAAF lesions.






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Copyright © 1981 by the Biophysical Society.