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Biophysical Journal 36: 321-327 (1981)
© 1981 the Biophysical Society

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The effect of tetramethylammonium on single sodium channel currents.

R Horn, J Patlak and C F Stevens

ABSTRACT

Voltage-dependent Na conductance of rat myotubes was studied by patch recordings of single-channels. The patches were excised from the cell with the patch electrode, and the cytoplasmic surface was bathed in either CsF or tetramethylammonium (TMA)-F. Inward currents were examined from -20 to -50 mV. In this range Cs and TMA both appeared to be nearly impermeant, but TMA blocked the channel in a voltage-dependent manner. A first-order blocking site was located a maximum of 89% of the way through the membrane field from the cytoplasmic surface.




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Single Ion Occupancy and Steady-state Gating of Na Channels in Squid Giant Axon
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Copyright © 1981 by the Biophysical Society.