Biophysical Journal 42: 151-157 (1983)
© 1983 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Clay, J R Articles by DeFelice, L J Search for Related Content PubMed PubMed Citation Articles by Clay, J R Articles by DeFelice, L J

Relationship between membrane excitability and single channel open-close kinetics.

ABSTRACT

We have developed a novel technique for simulating the influence of the effects of single channel kinetics on the voltage changes associated with membrane excitability. The technique uses probability distribution functions for the durations of channel open- and closed-state lifetimes, which can be calculated for any model of the ion conductance process. To illustrate the technique, we have used the Hodgkin and Huxley model of nerve membrane ion conductances to simulate channel kinetics during predetermined voltage changes, such as a voltage jump and an action potential. We have also simulated the influence of channels on voltage changes in a free running, non-voltage-clamped patch of membrane 1 micron2 or less in area. The latter results provide a direct illustration of the relationship between fluctuations of membrane excitability and fluctuations in channel open- and closed-state lifetimes.

This article has been cited by other articles:

				S. L. Mironov ADP Regulates Movements of Mitochondria in Neurons Biophys. J., April 15, 2007; 92(8): 2944 - 2952. [Abstract] [Full Text] [PDF]

				V. A. Maltsev and A. I. Undrovinas A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes Cardiovasc Res, January 1, 2006; 69(1): 116 - 127. [Abstract] [Full Text] [PDF]

				J. P. Hales, C. S.-Y. Lin, and H. Bostock Variations in excitability of single human motor axons, related to stochastic properties of nodal sodium channels J. Physiol., September 15, 2004; 559(3): 953 - 964. [Abstract] [Full Text] [PDF]

				S. M. Sine, X.-M. Shen, H.-L. Wang, K. Ohno, W.-Y. Lee, A. Tsujino, J. Brengmann, N. Bren, J. Vajsar, and A. G. Engel Naturally Occurring Mutations at the Acetylcholine Receptor Binding Site Independently Alter ACh Binding and Channel Gating J. Gen. Physiol., September 30, 2002; 120(4): 483 - 496. [Abstract] [Full Text] [PDF]

				R. J. Prince, R. A. Pennington, and S. M. Sine Mechanism of Tacrine Block at Adult Human Muscle Nicotinic Acetylcholine Receptors J. Gen. Physiol., August 26, 2002; 120(3): 369 - 393. [Abstract] [Full Text] [PDF]

				A. Manwani, P. N. Steinmetz, and C. Koch The Impact of Spike Timing Variability on the Signal-Encoding Performance of Neural Spiking Models Neural Comput., February 1, 2002; 14(2): 347 - 367. [Abstract] [Full Text] [PDF]

				A. Manwani and C. Koch Detecting and Estimating Signals in Noisy Cable Structures, I: Neuronal Noise Sources Neural Comput., November 15, 1999; 11(8): 1797 - 1829. [Abstract] [Full Text]

				M. Milone, H.-L. Wang, K. Ohno, T. Fukudome, J. N. Pruitt, N. Bren, S. M. Sine, and A. G. Engel Slow-Channel Myasthenic Syndrome Caused By Enhanced Activation, Desensitization, and Agonist Binding Affinity Attributable to Mutation in the M2 Domain of the Acetylcholine Receptor alpha  Subunit J. Neurosci., August 1, 1997; 17(15): 5651 - 5665. [Abstract] [Full Text] [PDF]