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Biophysical Journal 43: 121-125 (1983)
© 1983 the Biophysical Society

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The effect of receptor clustering on diffusion-limited forward rate constants.

B Goldstein and F W Wiegel

ABSTRACT

The effect of receptor clustering on the diffusion-limited forward rate constant (k+) is studied theoretically by modeling cell surface receptors by hemispheres distributed on a plane. We give both exact results and bounds. The exact results are obtained using an electrostatic analogue and applying the method of the images. Accurate upper bounds on k+ are found from a variational principle.




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M. Gopalakrishnan, K. Forsten-Williams, M. A. Nugent, and U. C. Tauber
Effects of Receptor Clustering on Ligand Dissociation Kinetics: Theory and Simulations
Biophys. J., December 1, 2005; 89(6): 3686 - 3700.
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Copyright © 1983 by the Biophysical Society.