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Biophysical Journal 45: 503-507 (1984)
© 1984 the Biophysical Society

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5-A Fourier map of gramicidin A phased by deuterium-hydrogen solvent difference neutron diffraction.

R E Koeppe, 2nd and B P Schoenborn

ABSTRACT

Crystals of ion-free gramicidin A (P212121: a = 24.61, b = 32.28, c = 32.52) have been investigated using neutron diffraction. A difference analysis of crystals soaked in ethanol/H2O as opposed to ethanol-d6/D2O has led to single isomorphous replacement Fourier projections of the structure at 5-A resolution. The gramicidin dimer appears to be a 32-A-long cylinder oriented parallel to the c-axis in these crystals.




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D. Langs
Three-dimensional structure at 0.86 A of the uncomplexed form of the transmembrane ion channel peptide gramicidin A
Science, July 8, 1988; 241(4862): 188 - 191.
[Abstract] [PDF]


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Copyright © 1984 by the Biophysical Society.