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Biophysical Journal 48: 85-91 (1985)
© 1985 the Biophysical Society

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Assessment of the symmetry of stem-cell mitoses.

M Bjerknes

ABSTRACT

A model of Paneth-cell renewal in the small intestinal epithelium is used to estimate the probability that epithelial stem-cell mitoses are symmetric in the sense that they produce two cells of the same type. I found that counts of the number of Paneth cells per crypt (Paneth cells are terminally differentiated cells derived from small intestinal epithelial stem cells) support a model in which most, if not all, stem-cell mitoses are symmetric.






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Copyright © 1985 by the Biophysical Society.