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Biophysical Journal 48: 349-353 (1985)
© 1985 the Biophysical Society

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Protons decrease the single channel conductance of the sarcoplasmic reticulum K+ channel in neutral and negatively charged bilayers.

J Bell

ABSTRACT

The conductance of rabbit sarcoplasmic reticulum K+ channels incorporated into artificial bilayers of varying lipid composition was measured at different K+ and proton concentrations. Protons competitively inhibit the K+ conductance with a Ki of 0.5 microM. In negatively charged membranes, the conductance is well described by Gouy-Chapman-Stern theory modified to include the inhibitory effect of protons of the conductance and assuming that the channel mouth is isolated by 5-10 A from bilayer surface.






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Copyright © 1985 by the Biophysical Society.