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Biophysical Journal 49: 1223-1227 (1986)
© 1986 the Biophysical Society

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A test of the stochastic theory of stem cell differentiation.

M Bjerknes

ABSTRACT

Stochastic theories of stem cell renewal are shown to predict turnover of intestinal crypts. While I found ample evidence of production of new crypts from direct in vivo studies in adult mice, I failed to find evidence of crypt loss. Thus, it would appear that the simple stochastic models may not provide an adequate theory of control of intestinal stem cell function.




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Copyright © 1986 by the Biophysical Society.