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Biophysical Journal 5: 27-46 (1965)
© 1965 the Biophysical Society

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A Mathematical Model of the Human Respiratory Control System

Howard T. Milhorn, Jr., Richard Benton, Richard Ross and Arthur C. Guyton

ABSTRACT

The respiratory system exhibits the properties of a control system of the regulator type. Equations describing this biological control system have been derived. Transient and steady-state solutions for various CO2 and O2 step input disturbances were obtained utilizing a digital computer and are compared with experimental results. The effectiveness of the respiratory system as a regulator is investigated. Further extensions of the model are suggested.






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Copyright © 1965 by the Biophysical Society.