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Biophysical Journal 5: 349-358 (1965)
© 1965 the Biophysical Society

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A Symbolic Model for the Regulation by Bone Metabolism of the Blood Calcium Level in Rats

Jean-Paul Aubert and Felix Bronner

ABSTRACT

The control by bone metabolism of the blood calcium level in young rats may be described in terms of a regulator-type system. The model presented here comprises a feedback loop involving only a proportional control in thyroparathyroidectomized, and a combination of proportional and integral controls in normal animals. It accounts for the variations observed when the system was subjected to a variety of experimental constraints. The implications, limitations, and possible extensions of the model are discussed.






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Copyright © 1965 by the Biophysical Society.