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Biophysical Journal 5: 935-945 (1965)
© 1965 the Biophysical Society

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Digital Computer Simulation of Respiratory Response to Cerebrospinal Fluid PCO2 in the Cat

J. D. Horgan and R. L. Lange

ABSTRACT

The respiratory control system is treated as linear with a transmission delay between ventilation and sensing points (chemoreceptors). To the accepted variables involving body gas stores, ventilatory effects, transmission effects, and steady state pH, PCO2, PO2 chemoreceptor response, certain detailed analysis of the central receptors have been added. By construction of a model for medullary CO2 receptor utilizing expected values of CNS (central nervous system) circulation, CO2 production, and tissue-buffering effects, results of experimental observation of the effects of alteration of CSF were simulated. The inclusion of CSF effects also allowed simulation of the response to alteration in inspired CO2, hyperventilation, and the periodic breathing with prolongation of circulation time.






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Copyright © 1965 by the Biophysical Society.