Biophysical Journal 50: 339-348 (1986)
© 1986 the Biophysical Society

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Optical imaging of cell membrane potential changes induced by applied electric fields.

ABSTRACT

We report the first imaging of the spatial distributions of transmembrane potential changes induced in nonexcitable cells by applied external electric fields. These changes are indicated by the fluorescence intensity of a charge-shift potentiometric dye incorporated in the cell plasma membrane and measured by digital intensified video microscopy.

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