Biophysical Journal 50: 861-874 (1986)
© 1986 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shrier, A Articles by Clay, J R Search for Related Content PubMed PubMed Citation Articles by Shrier, A Articles by Clay, J R

Repolarization currents in embryonic chick atrial heart cell aggregates.

ABSTRACT

Outward membrane currents in aggregates of atrial cells prepared from 7-12-d-old chick embryonic hearts were measured with the two microelectrode voltage-clamp technique. Two outward current components, Ix1 and Ix2, were found in the plateau potential range of the action potential. The Ix1 component is activated between -50 and -20 mV; the Ix2 component is activated between -15 and +20 mV. The Ix1 component inwardly rectifies, whereas Ix2 has an approximately linear current-voltage relation. These preparations lack a time-dependent pacemaker current component, even though they beat spontaneously with an interbeat interval of approximately 1 s. A mathematical model of electrical activity is described based on our measurements of time-dependent outward current, and measurements in the literature of inward current components.

This article has been cited by other articles:

				G.-R. Li, J. Feng, L. Yue, M. Carrier, and S. Nattel Evidence for Two Components of Delayed Rectifier K+ Current in Human Ventricular Myocytes Circ. Res., April 1, 1996; 78(4): 689 - 696. [Abstract] [Full Text]

				M. W. Veldkamp, A. C.G. van Ginneken, T. Opthof, and L. N. Bouman Delayed Rectifier Channels in Human Ventricular Myocytes Circulation, December 15, 1995; 92(12): 3497 - 3504. [Abstract] [Full Text]