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Biophysical Journal 51: 673-680 (1987)
© 1987 the Biophysical Society

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A General Method for Modeling Macromolecular Shape in Solution

A Graphical (II-G) Intersection Procedure for Triaxial Ellipsoids

Stephen E. Harding

ABSTRACT

A general method for modeling macromolecular shape in solution is described involving measurements of viscosity, radius of gyration, and the second thermodynamic virial coefficient. The method, which should be relatively straightforward to apply, does not suffer from uniqueness problems, involves shape functions that are independent of hydration, and models the gross conformation of the macromolecule in solution as a general triaxial ellipsoid. The method is illustrated by application to myosin, and the relevance and applicability of ellipsoid modeling to biological structures is discussed.




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Y. Lu, E. Longman, K. G. Davis, A. Ortega, J. G. Grossmann, T. E. Michaelsen, J. G. de la Torre, and S. E. Harding
Crystallohydrodynamics of Protein Assemblies: Combining Sedimentation, Viscometry, and X-Ray Scattering
Biophys. J., September 1, 2006; 91(5): 1688 - 1697.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the Biophysical Society.