help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Biophysical Journal 52: 347-350 (1987)
© 1987 the Biophysical Society

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zucker, R S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zucker, R S

The calcium hypothesis and modulation of transmitter release by hyperpolarizing pulses.

R S Zucker

Department of Physiology-Anatomy, University of California, Berkeley 94720.

ABSTRACT

Small presynaptic conditioning hyperpolarizing pulses reduce transmitter release to a depolarizing stimulus by a substantial amount, with little effect on release by a subsequent depolarization. This result, obtained at neuromuscular junctions and the squid giant synapse, has been offered as a disproof of the calcium hypothesis of transmitter release or the residual calcium hypothesis of synaptic facilitation. However, calculations based on several formulations of these hypotheses are shown to be consistent with the experimental results, and no fundamental modification of the hypotheses is necessary.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. Ravin, H. Parnas, M. E. Spira, and I. Parnas
Partial Uncoupling of Neurotransmitter Release From [Ca2+]i by Membrane Hyperpolarization
J Neurophysiol, June 1, 1999; 81(6): 3044 - 3053.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by the Biophysical Society.