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Biophysical Journal 52: 501-505 (1987)
© 1987 the Biophysical Society

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Uranyl acetate induces gel phase formation in model lipid and biological membranes.

M Caffrey, S J Morris and G W Feigenson

Department of Chemistry, Ohio State University, Columbus 43210-1173.

ABSTRACT

The effect of uranyl acetate on the mesomorphic phase state of lipids in model membranes as well as in isolated biological membranes has been examined. As little as 0.8 mM (0.03% [wt/vol]) uranyl acetate induces a liquid crystal-to-gel phase transformation in egg phosphatidic acid, bovine brain phosphatidylserine, and in lysed chromaffin granule membranes. These results along with others in the literature indicate that the uranyl acetate used in samples for electron microscopy could alter membrane morphology.






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Copyright © 1987 by the Biophysical Society.