Biophysical Journal 54: 871-877 (1988)
© 1988 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Korn, S J Articles by Horn, R Search for Related Content PubMed PubMed Citation Articles by Korn, S J Articles by Horn, R

Statistical discrimination of fractal and Markov models of single-channel gating.

Neurosciences Department, Roche Institute of Molecular Biology, Nutley, New Jersey 07110.

ABSTRACT

A statistical comparison is presented of Markov and fractal models of ion channel gating. The analysis is based on single-channel data from two types of ion channels: open times from a 90 pS Ca-activated K channel from GH3 pituitary cells, and closed times from a nonselective channel from rabbit corneal endothelium (Liebovitch et al., 1987a). Maximum likelihood methods were used to fit the data. For both data sets the best Markov model had three exponential components. The best Markov model had a higher likelihood than the fractal model, and the Asymptotic Information Criterion favored the Markov model for each data set. A more detailed analysis, using the Monte Carlo methods described in Horn (1987), showed that the Markov model was not significantly better than the fractal model for the corneal endothelium channels. The inability to discriminate the models definitively in this case was shown to be due in part to the small size of the data set.

This article has been cited by other articles:

				B. L. Jones, P. J. Whiting, and L. P. Henderson Mechanisms of anabolic androgenic steroid inhibition of mammalian {varepsilon}-subunit-containing GABAA receptors J. Physiol., June 15, 2006; 573(3): 571 - 593. [Abstract] [Full Text] [PDF]

				L. Csanady Statistical Evaluation of Ion-Channel Gating Models Based on Distributions of Log-Likelihood Ratios Biophys. J., May 15, 2006; 90(10): 3523 - 3545. [Abstract] [Full Text] [PDF]

				G. Michels, F. Er, I. Khan, M. Sudkamp, S. Herzig, and U. C. Hoppe Single-Channel Properties Support a Potential Contribution of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and If to Cardiac Arrhythmias Circulation, February 1, 2005; 111(4): 399 - 404. [Abstract] [Full Text] [PDF]

				D. Bichet, Y.-F. Lin, C. A. Ibarra, C. S. Huang, B. A. Yi, Y. N. Jan, and L. Y. Jan Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity PNAS, March 30, 2004; 101(13): 4441 - 4446. [Abstract] [Full Text] [PDF]