Biophysical Journal 55: 1267-1271 (1989)
© 1989 the Biophysical Society

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Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.

Max-Planck-Institut für biophysikalische Chemie, Göttingen, Federal Republic of Germany.

ABSTRACT

Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.

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