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Biophysical Journal 59: 765-774 (1991)
© 1991 the Biophysical Society

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Effect of aniosmotic media on the volume of the T-lymphocyte nucleus.

A G Hoekstra, J A Aten and P M Sloot

Department of Biophysics, The Netherlands Cancer Institute, Amsterdam.

ABSTRACT

Time-resolved measurements of the nuclear volume response of human peripheral T-lymphocytes, under aniosmotic conditions, are presented. In the experiments slit scanning FlowCytometry methods were used. We propose an extension to the standard solid viscoelastic model to interpret the observed dynamical behavior of the nucleus. It is shown that experimental and theoretical evidence indicates a passive nuclear response merely induced by a mechanical link (i.e., the cytoskeleton) between the cell membrane and the nuclear envelope. Implications of this work to the field of cellular mechanics and cytoskeletal rheology are surveyed.






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Copyright © 1991 by the Biophysical Society.