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Biophysical Journal 59: 880-888 (1991)
© 1991 the Biophysical Society

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Cross-helix separation of tropomyosin molecules in acto-tropomyosin as determined by neutron scattering.

D B Bivin, D B Stone, D K Schneider and R A Mendelson

Cardiovascular Research Institute, University of California, San Francisco 94143.

ABSTRACT

The cross-helix separation of Tm molecules in acto-tropomyosin has been determined using neutron scattering. Deuterated Dictyostelium discoideum actin was density matched in a 93% D2O buffer so that effectively only the protonated tropomyosin was "visible" to neutrons. Analysis of the solution scattering pattern in the region of the first oscillation yielded a value for the cross-helix separation of 7.9 +/- 0.3 nm. The implications of this value for the mechanism of the regulation of muscle contraction are discussed in light of recent results by others.






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Copyright © 1991 by the Biophysical Society.