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Biophysical Journal 60: 81-88 (1991)
© 1991 the Biophysical Society

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Electrostatic modeling of dipole-ion interactions in gramicidinlike channels

M. Sancho and G. Martínez

Departamento de Física Aplicada III, Facultad de Física, Universidad Complutense, 28040, Madrid, Spain

ABSTRACT

Using an electrostatic model for the pore and membrane region in a gramicidinlike channel, the effect of dipoles located inside the membrane on the ion transport are analyzed. Calculated energy profiles for different orientations of dipoles show a predominant influence of their radial components. The results qualitatively agree with experimental measurements of conductance on different modified gramicidins and allow to understand the important role of polar side chains on ion permeation.






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Copyright © 1991 by the Biophysical Society.