Biophysical Journal 60: 433-439 (1991)
© 1991 the Biophysical Society

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Estimating the number of channels in patch recordings

Neurosciences Department, Roche Institute of Molecular Biology, Nutley, New Jersey 07110 USA

ABSTRACT

The estimation of the number of channels in a patch was assumed to be equivalent to the estimation of the binomial parameter n. Seven estimators were evaluated, using data sets simulated for a range of parameters appropriate for single channel recording experiments. No single estimator was best for all parameters; a combination of estimators is a possible option to avoid the biases of individual estimators. All estimators were highly accurate in estimating n in the case that n = 1. For n 4 the simplest estimator, the maximum number of simultaneously open channels, was the best, For larger values of n the best estimators were Bayesian.

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