Biophysical Journal 61: 827-830 (1992)
© 1992 the Biophysical Society

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Constant helical pitch of the gramicidin channel in phospholipid bilayers.

Department of Physics, University of Guelph, Ontario, Canada.

ABSTRACT

X-ray diffraction has been applied in measuring the helical pitch of the gramicidin channel in oriented bilayers of dilauroylphosphatidylcholine (DLPC) and dimyristoylphosphatidylcholine (DMPC) at a polypeptide concentration of 9.1 mol %. The diffraction data show the helical pitch of gramicidin to be 4.7 +/- 0.2 A in both gel and liquid-crystalline phase bilayers, with and without monovalent cations. In addition, the width of the reflection due to the pitch of the helical gramicidin channel is consistent with a five turn helix.

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