Biophysical Journal 61: 936-940 (1992)
© 1992 the Biophysical Society

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Cryo-EM of the native structure of the calcium release channel/ryanodine receptor from sarcoplasmic reticulum.

Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.

ABSTRACT

The native structure of the calcium release channel (ryanodine receptor) from rabbit skeletal muscle has been analyzed in two dimensions from electron micrographs of frozen hydrated specimens. Within a resolution of 3.0 nm there is excellent agreement between the structure as seen in vitreous water and in negative stained specimens. Features seen in the three-dimensional reconstruction of the negatively stained channel can be identified in the projection of the unstained receptor.

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